Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress (2024)

Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress

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* Corresponding authors

a School of Food and Biological Engineering, Jiangsu University, Zhenjiang, P. R. China
E-mail: mhl@ujs.edu.cn
Fax: +86 51188790958
Tel: +86 51188790958

b School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, P. R. China

Abstract

Non-alcoholic fatty liver disease (NAFLD) is increasingly threatening human health. The remarkable effects of corn peptides (CPs) as bioactive peptides on liver protection have attracted much attention. Nevertheless, the specific effect of CPs on NAFLD remains unclear. The present study was designed to investigate the efficacy of CPs in the prevention and auxiliary treatment of high-fat diet (HFD)-induced NAFLD in SD rats, and puerarin was used as the positive control. SD rats were fed a high-fat diet to establish the NAFLD rat model, and LO2 cells were treated with a high concentration of fructose to simulate the NAFLD cell model. NAFLD was comprehensively examined in terms of body weight, liver function markers, serum biochemistry and liver histology. Protein expression was determined using western blot analysis. The results of animal experiments showed that CPs could effectively inhibit the rate of weight gain, reduce the blood lipid level and liver index, and enhance glucose tolerance. The results of cell experiments showed that CPs could effectively reduce the accumulation of lipids in LO2 cells and inhibit the accumulation of reactive oxygen species (ROS). In addition, CPs could markedly reduce liver lipid accumulation in the liver cell and liver tissue, as further evidenced by the reduced expression of SREBP-1c in human non-tumour hepatic (LO2) cells. Meanwhile, the increased expression of SIRT1/PPAR-α and Nrf2/HO-1 pathways under the pretreatment of CPs in LO2 cells indicated that CPs could markedly relieve high fat-induced fatty liver injury, regulate insulin sensitivity, and reduce production of ROS. The results of in vivo and in vitro experiments demonstrated that CPs provided potential prevention and auxiliary treatment for NAFLD through reducing lipid accumulation, alleviating insulin resistance, and inhibiting oxidative stress. This study investigated the biological activity of CPs and laid the theoretical basis for the development of CP-based functional foods and dietary supplements.

Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress (3)

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Article type
Paper

Submitted
19 Jan 2022

Accepted
25 Mar 2022

First published
01 Apr 2022

Food Funct., 2022,13, 5782-5793

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Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress

K. Wei, Y. Wei, W. Xu, F. Lu and H. Ma, Food Funct., 2022,13, 5782 DOI: 10.1039/D2FO00199C

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Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress (2024)

FAQs

Is corn good for fatty liver disease? ›

Conclusion: Corn peptides improved cell injury and ameliorated mitochondrial dysfunction and lipid accumulation via PINK1/Parkin-mediated autophagy in NAFLD. Thus, corn peptides could be a promising nutritional molecule with natural functions for preventing NAFLD.

What is the best diet for non alcoholic fatty liver disease? ›

A diet high in fruits and vegetables will help your body combat and control NAFLD. In addition, it can help you lose weight and prevent or control type II diabetes.  Eat 4-5 servings of vegetables daily. Choose non-starchy vegetables.

What peptides are used for non alcoholic fatty liver disease? ›

Metabolitin is a newly identified peptide hormone that significantly improves fatty liver. The major mechanism by which metabolitin improves NAFLD is by inhibiting fat absorption in the intestines.

What are the worst foods for fatty liver? ›

Avoid when possible

High blood sugar increases the amount of fat buildup in the liver. Fried foods: These are high in fat and calories. White bread, rice, and pasta: White flour is typically highly processed, and items made from it can raise your blood sugar more than whole grains due to a lack of fiber.

What is the best vitamin for liver repair? ›

Vitamin B. Studies have shown that B vitamins can benefit liver function in several ways, including reversing liver inflammation. Many B vitamins, including vitamin B12 and folic acid, can improve liver health in people with fatty liver disease.

Can losing weight reverse non alcoholic fatty liver? ›

Fortunately, NAFLD and NASH are reversible, as is liver fibrosis, especially before cirrhosis is well-established. The cornerstone of therapy is weight loss, as a reduction in body mass index (BMI) of 5% is associated with a 25% relative reduction in liver fat as measured by magnetic resonance imaging (MRI) [7].

What is the new drug for non-alcoholic fatty liver disease? ›

Rates of a serious form of liver disease have grown, but there have been no medications to treat it—until now. In March, the U.S. Food and Drug Administration (FDA) approved a pill called resmetirom, sold under the brand name Rezdiffra™, for NASH (nonalcoholic steatohepatitis).

What is the best protein for fatty liver disease? ›

Take as much of your protein from vegetable sources as possible. Vegetable protein is better tolerated than dairy or meat. Try lentils, beans, peas, nuts, oatmeal, wild rice, and soybean products such as soy milk, tofu and edamame.

What are the best vitamins for non-alcoholic fatty liver disease? ›

Vitamin E. In theory, vitamin E and other vitamins called antioxidants could help protect the liver by reducing or canceling out the damage caused by inflammation. But more research is needed. Some evidence suggests vitamin E supplements may be helpful for people with NAFLD who don't have type 2 diabetes.

Can you eat popcorn if you have fatty liver? ›

Make at least half of your grain products whole grain each day. 1/2 cup cooked rice, pasta, cereal, couscous or bulgur Whole grain breads, hot and cold cereals, pasta, brown rice, couscous or bulgur. Low fat snack foods such as air popped popcorn and low sodium pretzels.

When should you not eat corn? ›

However, some people should limit or avoid corn. Usually, corn is only a problem when consumed in excess. People with diabetes may want to use caution since carbohydrates, like corn, can spike blood sugar. Similarly, people wanting to lose weight may want to limit how much corn they eat.

Are boiled eggs good for fatty liver? ›

According to a study led by the University of North Carolina, choline deficiency may contribute to the development of fatty liver disease. Including choline-rich foods like eggs in the diet may help maintain optimal liver function. While egg yolks can be part of a balanced and nutrient-rich diet, moderation is crucial.

Are potatoes ok for fatty liver? ›

The researchers concluded that it is advisable to consume a fist-sized amount of 'healthy' carbohydrates naturally containing resistant starch, such as wholegrain cereals, legumes, green bananas, and starchy vegetables like potatoes at every meal to alleviate fatty liver.

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